全文获取类型
收费全文 | 128971篇 |
免费 | 8088篇 |
国内免费 | 1228篇 |
专业分类
耳鼻咽喉 | 2044篇 |
儿科学 | 1995篇 |
妇产科学 | 1927篇 |
基础医学 | 20494篇 |
口腔科学 | 3149篇 |
临床医学 | 11966篇 |
内科学 | 22592篇 |
皮肤病学 | 4153篇 |
神经病学 | 10468篇 |
特种医学 | 7512篇 |
外国民族医学 | 3篇 |
外科学 | 17474篇 |
综合类 | 731篇 |
现状与发展 | 3篇 |
一般理论 | 33篇 |
预防医学 | 6613篇 |
眼科学 | 3319篇 |
药学 | 11822篇 |
3篇 | |
中国医学 | 1584篇 |
肿瘤学 | 10402篇 |
出版年
2023年 | 703篇 |
2022年 | 548篇 |
2021年 | 3857篇 |
2020年 | 2241篇 |
2019年 | 3112篇 |
2018年 | 3903篇 |
2017年 | 3160篇 |
2016年 | 4133篇 |
2015年 | 5737篇 |
2014年 | 6827篇 |
2013年 | 7891篇 |
2012年 | 11811篇 |
2011年 | 11367篇 |
2010年 | 6551篇 |
2009年 | 5595篇 |
2008年 | 7942篇 |
2007年 | 7520篇 |
2006年 | 6774篇 |
2005年 | 6297篇 |
2004年 | 5430篇 |
2003年 | 4707篇 |
2002年 | 4080篇 |
2001年 | 3074篇 |
2000年 | 2827篇 |
1999年 | 2166篇 |
1998年 | 844篇 |
1997年 | 648篇 |
1996年 | 473篇 |
1995年 | 473篇 |
1994年 | 406篇 |
1993年 | 344篇 |
1992年 | 771篇 |
1991年 | 718篇 |
1990年 | 650篇 |
1989年 | 569篇 |
1988年 | 468篇 |
1987年 | 476篇 |
1986年 | 344篇 |
1985年 | 375篇 |
1984年 | 274篇 |
1983年 | 198篇 |
1982年 | 136篇 |
1981年 | 175篇 |
1980年 | 132篇 |
1979年 | 228篇 |
1978年 | 165篇 |
1977年 | 122篇 |
1976年 | 138篇 |
1975年 | 123篇 |
1974年 | 145篇 |
排序方式: 共有10000条查询结果,搜索用时 265 毫秒
71.
72.
73.
Dong Kyu Kim Joon Ho Kwon Heung Kyu Ko Junhyung Lee Kichang Han Gyoung Min Kim Man-Deuk Kim Jong Yun Won Hyun-Chel Joo Young-Guk Ko Do Yun Lee 《Journal of vascular and interventional radiology : JVIR》2021,32(1):39-48
PurposeTo evaluate the feasibility, safety, and effectiveness of N-butyl cyanoacrylate (NBCA) embolization for the treatment of aortic dissection.Materials and MethodsIn this single-center retrospective study conducted from February 2003 to June 2019, NBCA embolization of an aortic false lumen was attempted in 12 patients (median age, 59 y; range, 41–68 y) and thoracic endovascular aortic repair (TEVAR) was performed in 53 patients (median age, 59 y; range, 37–70 y) for aortic dissection with one or more indications of persisting pain, malperfusion, rupture or impending rupture, maximal aortic diameter ≥ 55 mm, and/or rapid aortic enlargement. The main exclusion criterion for embolization was the presence of fast blood flow in the aortic false lumen on aortography. The efficacy of NBCA embolization and TEVAR was compared by evaluating technical and clinical outcomes, repeat intervention–free survival (RFS), and overall survival (OS).ResultsTechnical success was achieved in 11 of the 12 patients treated with NBCA embolization (91.7%), and clinical success was achieved in 9 of these 11 (81.8%). No significant difference was found between embolization and TEVAR in clinical success rates (embolization, 81.8%; TEVAR, 84.9%; P = .409) or procedure-related complications (embolization, 1 patient [8.3%]; TEVAR, 4 patients [7.5%]; P = .701). In addition, embolization showed comparable 5-y RFS (embolization, 82.5% ± 9.3; TEVAR, 85.5% ± 4.8; P = .641) and 5-y OS (embolization, 100%; TEVAR, 95.4% ± 3.2; P = .744) rates to TEVAR.ConclusionsNBCA embolization of the false lumen in aortic dissection seems to be a safe and effective treatment modality for the closure of false lumen in selected patients. 相似文献
74.
75.
76.
77.
Stefano Cascinu György Bodoky Kei Muro Eric Van Cutsem Sang Cheul Oh Gunnar Folprecht Sumitra Ananda Gustavo Girotto Zev A. Wainberg Maria Luisa Limon Miron Jaffer Ajani Ran Wei Astra M. Liepa Roberto Carlesi Michael Emig Atsushi Ohtsu 《The oncologist》2021,26(3):e414-e424
BackgroundIn the intent‐to‐treat (ITT) population of the RAINBOW study, objective response rate (ORR) was 28% and 16% in the ramucirumab and control arms, respectively. To further characterize tumor response, we present details on timing and extent of tumor shrinkage, as well as associations with symptom palliation.Materials and MethodsTumor response was assessed with RECIST v1.1, and quality of life (QoL) was assessed with the European Organization for Research and Treatment of Cancer Quality‐of‐Life Questionnaire‐Core 30 (EORTC QLQ‐C30) v3.0. Prespecified and post hoc analyses were conducted in the ITT population, patients with measurable disease, or responders, and included best overall response (BOR), ORR, disease control rate (DCR), duration of response, time to response (TtR), change in tumor size, and associations of QoL with tumor shrinkage and BOR.ResultsIn both treatment arms, median TtR was 1.5 months. Responses were more durable in the ramucirumab versus control arm (median 4.4 vs. 2.8 months). In patients with measurable disease (78% of ITT), ORR was 36% versus 20%; DCR was 81% versus 61% in the ramucirumab versus control arms. Waterfall plots demonstrated more tumor shrinkage in the ramucirumab versus control arm. Regardless of treatment, tumor response and stable disease were associated with improved or stable QoL, with more tumor shrinkage associated with greater symptom palliation.ConclusionTreatment with ramucirumab plus paclitaxel yielded the highest ORR reported to date for patients with previously treated advanced gastric or gastroesophageal junction adenocarcinoma. Additional details demonstrate robustness of tumor response results. The extent of tumor shrinkage is directly associated with symptom palliation and should be considered when evaluating patient needs and treatment selection. Clinical trial identification number. .Implications for PracticeRamucirumab plus paclitaxel is a recognized standard of care as it improves survival for patients with advanced gastric or gastroesophageal junction adenocarcinoma who have been previously treated with recommended first‐line therapy. These additional data on tumor response demonstrate a positive association between tumor shrinkage and symptom palliation in a patient population that is often symptomatic. These observations included patients with nonmeasurable disease, a group of patients often underrepresented in clinical trials. This knowledge can inform treatment decisions, which align individual patient characteristics and needs with demonstrated benefits. NCT01170663相似文献
78.
Jung-Woo Shim Jemin Ko Chul-Seung Lee Do-Sang Lee Jaesik Park Hyung Mook Lee Yong-Suk Kim Young Eun Moon Sang Hyun Hong Min Suk Chae 《Asian journal of surgery / Asian Surgical Association》2021,44(1):254-261
BackgroundThis study investigated the optimal timing of analgesic transversus abdominis plane (TAP) block in the operating room for better recovery quality using the Korean version of the Quality of Recovery-40 (QoR-40K) questionnaire in patients who had undergone open inguinal herniorrhaphy.MethodsThis single-centre, prospective randomised controlled study included adult male patients who had an ASA physical status of I–II. A total of 80 patients were analysed. The patients were randomly assigned and classified into pre-incisional TAP (pre-TAP) block (n = 40) and post-incisional TAP (post-TAP) block (n = 40) groups. The quality of postoperative functional recovery and complications were compared between the two groups during 24 h postoperatively.ResultsPreoperative findings of the two groups were comparable. The global QoR-40K score was higher in the pre-TAP group than in the post-TAP group. Among sub-dimensions, scores of physical comfort and pain were higher in the pre-TAP group than in the post-TAP group. In the post-anaesthesia care unit, the pre-TAP group showed lower pain scores than the post-TAP block group. There was no severe pain in the pre-TAP group, but two patients (5.0%) in the post-TAP block group suffered severe pain. The pre-TAP group required lower doses of IV rescue opioid in the PACU than the post-TAP group. All patients were discharged from hospital on postoperative day 1 without surgical complications.ConclusionsThe timing of analgesic TAP block may be of clinical importance to prevent postoperative pain and to improve the quality of early patient recovery following open inguinal herniorrhaphy. 相似文献
79.
Hypoxic stress is linked to various cardiovascular disorders (e.g., stroke, myocardial infarction), mediated, at least in part, by a reduction in ATP synthesis. Fructose-driven glycolysis is proposed as an alternative pathway capable of sustaining ATP production even under anoxic conditions. Here, we tested the hypothesis that facilitating fructose-driven metabolism exerts a protective effect against anoxic stress in Drosophila. Genetically modified flies with the human fructose transporter (GluT5) and ketohexokinase (KHK) genes downstream of upstream activating sequence (UAS) were constructed. The GAL4-UAS system was confirmed to: (i) increase the expression of GluT5 and KHK in a tissue-specific and a time-dependent manner (i.e., whole flies [with Act5c-gene switch GAL4 driver], neurons [with elav-gene switch GAL4 driver]) and (ii) reduce mortality of flies when placed under anoxic stress. Taken together, these data suggest that increasing fructose metabolism may be a clinically relevant approach to minimize hypoxia-induced cellular damage. 相似文献
80.
Cheng Shi Chen Alrashidi Ibrahim Ji Hoon Shin Hai-Liang Li Hye Hyeon Moon Hee Ho Chu Jong Woo Kim 《Journal of vascular and interventional radiology : JVIR》2021,32(1):135-140
Six patients (mean age, 57.7 y ± 19.7) with persistent urinary fistulae underwent 7 urinary tract embolizations with AMPLATZER Vascular Plugs (AVPs) and glue: 5 with concomitant cavity obliteration with glue and 2 without. A single procedure was successful in resolving urinary leakage in 5 patients (71%) at a mean follow-up of 27.3 wk ± 31.5 (median, 9.7 wk; range, 4.9–80 wk). Repeat cavity embolization was required in 2 instances to achieve clinical success. Mean survival was 42.3 wk (median, 16.4 wk; range, 11.7–104 wk). Combined AVP and glue embolization may prove to be a primary approach in the control of persistent fistulae. 相似文献